Selected Publications

 

1.     A Oken, J Lee, S David, Q Xie, C Dennison and JZ Chen (2019). "Z-contrast enhancement enables cryo-EM structure determination of a 47 kDa protein."  Submitted.

2.     JZ Chen (2019).  "#Protein lights up in cryo-EM."  Microscopy and Microanalysis 25 (S2): 1222-1223. DOI:10.1017/S1431927619006846.

3.     WC Thomas, FP Brooks, AA Burnim, JP Bacik, J Stubbe, JT Kaelber, JZ Chen and N Ando (2019). "Convergent allostery in ribonucleotide reductase."  Nature Communications 10(1): 2653.

4.     JZ Chen (2018).  "Single-Particle 3D Reconstruction beyond the Nyquist Frequency."  Proceedings of IEEE International Conference on Bioinformatics and Biomedicine, 2018: 2442-2445.

5.     BL Brown, EF Vieux, T Kalastavadi, S Kim, JZ Chen and TA Baker (2018). "N domain of the Lon AAA+ protease controls assembly and substrate choice." Protein Science, PMID: 30461098.

6.     JF Fay, LA Aleksandrov, TJ Jensen, LL Cui, JN Kousouros, L He, AA Alexsandrov, DS Gingerich, JR Riordan* and JZ Chen* (2018).  "Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel."  Biochemistry 57(43): 6234-6246.

7.     P Monette, R Brach, A Cowan, R Winters, J Weisman, F Seybert, K Goguen, JZ Chen, A Glasfeld and G Spatafora (2018).  "Autoregulation of the Streptococcus mutans SloR Metalloregulator is Constitutive and Driven by an Independent Promoter."  Journal of Bacteriology 200(14).  PMID: 29735764.

8.     GM Martin, C Yoshioka, EA Rex, Q Xie, MR Whorton, JZ Chen*, SL Shyng* (2017).  "Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating." eLife 2017; 6:e24149. PMID: 28092267. (* Co-communication authors)

9.     R Marabini, B Carragher, S Chen, JZ Chen, A Cheng, KH Downing, J Frank, RA Grassucci, H Bernard, W Jiang, S Jonic, HY Liao, SJ Ludtke, S Patwari, AL Piotrowski, A Quintana, CO Sorzano, H Stahlberg, J Vargas, NR Voss, W Chiu and JM Carazo (2015).  "CTF Challenge: Result Summary."  Journal of Structural Biology 190(3): 348-359.

10.  BA Sosa, FE Demircioglu, JZ Chen, J Ingram, HL Ploegh and TU Schwartz (2014).  "How lamina-associated polypeptide 1 (LAP1) activates Torsin."  eLife 2014; 3:e03239.  PMID: 25149450.

11.  D Barthelme*, JZ Chen*, J Grabenstatter, TA Baker and RT Sauer (2014).  "Architecture and assembly of the archaeal Cdc48*20S proteasome."  PNAS 111(17): E1687-1694.        (* Co-first authors)

12.  KR Andersen, E Onischenko, JH Tang, P Kumar, JZ Chen, A Ulrich, JT Liphardt, K Weis and TU Schwartz (2013).  "Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors."  Elife 2: e00745.

13.  EF Vieux, ML Wohlever, JZ Chen, RT Sauer and TA Baker (2013).  "Distinct quaternary structures of the AAA+ Lon protease control substrate degradation."  PNAS 110(22): E2002-2008.

14.  AF Brilot, JZ Chen, A Cheng, J Pan, SC Harrison, CS Potter, B Carragher, R Henderson and N Grigorieff (2012).  "Beam-induced motion of vitrified specimen on holey carbon film."  Journal of Structural Biology 177(3): 630637.

15.  R Henderson, S Chen, JZ Chen, N Grigorieff, LA Passmore, L Ciccarelli, JL Rubinstein, RA Crowther, PL Stewart, PB Rosenthal (2011).  "Tilt-Pair Analysis of Images from a Range of Different Specimens in Single-Particle Electron Cryomicroscopy."  Journal of Molecular Biology 413(5): 1028-1046.

16.  EC Settembre*, JZ Chen*, PR Dormitzer, N Grigorieff and SC Harrison (2011). "Atomic model of an infectious rotavirus particle."  EMBO J. 30(2): 408-416. (* Co-first authors)

17.  JZ Chen*, EC Settembre*, ST Aoki, X Zhang, AR Bellamy, PR Dormitzer, SC Harrison and N Grigorieff (2009). "Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM."  PNAS 106(26): 10644-10648. (* Co-first authors)

18.  JZ Chen, C Sachse, C Xu, T Mielke, C Spahn and N Grigorieff (2008). "A Dose-Rate Effect in Single-Particle Electron Microscopy."  Journal of Structural Biology 161(1): 92-100.

19.  C Sachse, JZ Chen, P Coureux, ME Stroupe, M Fandrich and N Grigorieff (2007).  "High-Resolution Electron Microscopy of Helical Specimens: A Fresh Look at Tobacco Mosaic Virus."  Journal of Molecular Biology 317(3): 812-835.

20.  JZ Chen and N Grigorieff (2006). "SIGNATURE: A single-particle selection system for molecular electron microscopy." Journal of Structural Biology 157(1): 168-173.

21.  TR Shaikh, DR Thomas, JZ Chen, FA Samatey, H Matsunami, K Imada, K Namba and DJ DeRosier (2004). "A Partial Atomic Structure for the Flagellar Hook of Salmonella Typhimurium." PNAS 102(4): 1023-1028.

22.  FA Samatey, H Matsunami, K Imada, S Nagashima, TR Shaikh, DR Thomas, JZ Chen, DJ DeRosier, A Kitao and K Namba (2004). "Structure of the Bacterial Flagellar Hook and Implication for the Molecular Universal Joint Mechanism." Nature 431: 1062-1068.

23.  JZ Chen, J Furst, MS Chapman and N Grigorieff (2003). "Low-Resolution Structure Refinement in Electron Microscopy." Journal of Structural Biology 144: 144-151.

24.  J Furst, RB Sutton, JZ Chen, AT Brunger and N Grigorieff (2003). "Electron Cryomicroscopy Structure of N-Ethyl Maleimide Sensitive Factor at 11 Resolution." The EMBO Journal 22(17): 4365-4374.

25.  SM Pizer, PT Fletcher, S Joshi, A Thall, JZ Chen, Y Fridman, DS Fritsch, AG Gash, JM Glotzer, MR Jiroutek, CL Lu, KE Muller, G Tracton, P Yushkevich and EL Chaney (2003). "Deformable M-reps for 3D Medical Image Segmentation." International Journal of Computer Vision 55: 85-106.

26.  JZ Chen, SM Pizer, EL Chaney and S Joshi (2002). "Medical Image Synthesis via Monte Carlo Simulation." Medical Image Computing and Computer Assisted Intervention 2488: 347-354.

27.  SM Pizer, S Joshi, T Fletcher, M Styner, G Tracton and JZ Chen (2001). "Segmentation of Single-Figure Objects by Deformable M-reps." Medical Image Computing and Computer Assisted Intervention 2208: 862-869.

28.  JZ Chen and MS Chapman (2001). "Conformational Disorder of Proteins Assessed by Real Space Molecular Dynamics Refinement." Biophysical Journal 80: 1466-1472.

29.  JZ Chen, E Blanc and MS Chapman (1999). "Real Space Molecular Dynamics Structural Refinement." Acta Crystallographica D55: 464-468.

30.  JZ Chen, E Blanc and MS Chapman (1999). "Improved Free R-factors for the Cross Validation of Macromolecular Structures." Acta Crystallographica D55: 219-224.